Princeton University

School of Engineering & Applied Science

Towards an Artificial Pancreas for Type-1 Diabetes: Control Theory Implications

Graham Goodwin, The University of Newcastle
Friend Center, Convocation Room
Tuesday, September 16, 2014 - 12:30pm

Diabetes is a major health issue in the world. Over 8% of Americans suffer from some form of diabetes and approximately 10% of these have Type 1 diabetes. The usual treatment for these patients is to externally apply insulin so as to lower blood glucose levels. Prolonged high blood glucose levels (hyperglycaemia) can lead to long term health issues including cardiovascular disease and blindness. Extremely low blood glucose levels (hypoglycaemia) can lead to coma and even death.
Due to the central importance of diabetes as a public health issue, there has been substantial effort aimed at improving treatment options. In recent years, continuous blood glucose measurements (CGM) and insulin infusion pumps (IIP) have been developed. The availability of these devices has led to the possibility of autonomous closed loop control of blood glucose levels by interconnecting a CGM and an IIP via a computer based control algorithm. This is commonly termed an “Artificial Pancreas”.
The talk will emphasize control theoretic issues associated with the development of an Artificial Pancreas including;

  • Fundamental control system design limitations
  • The importance of feedforward
  • The potential advantages of preview

Graham Goodwin graduated from the University of New South Wales with B.Sc. (Physics) 1965, B.E. Honours I (Electrical Engineering) 1967 and Ph.D. 1971. In 2010 he was awarded the IEEE Control Systems Field Award and in 2013 he received the Rufus T. Oldenburger Medal from the American Society of Mechanical Engineers. Other international awards include the 1999 IEEE Control Systems Society Hendrik Bode Lecture Prize, a Best Paper award by IEEE Transactions on Automatic Control, a Best Paper award by Asian Journal of Control, and two Best Engineering Text Book awards from the International Federation of Automatic Control in (1984 and 2005). He received the 2008 Quazza Medal from the International Federation of Automatic Control, the 2010 Nordic Process Control Award, and the 2011 Asian Control Association Wook Hyun Kwon Education Award. He is a Fellow of IEEE; an Honorary Fellow of Institute of Engineers, Australia; a Fellow of the International Federation of Automatic Control, a Fellow of the Australian Academy of Science; a Fellow of the Australian Academy of Technology, Science and Engineering; a Member of the International Statistical Institute; a Fellow of the Royal Society, London and a Foreign Member of the Royal Swedish Academy of Sciences. He holds Honorary Doctorates from Lund Institute of Technology, Sweden and the Technion Israel. He is the co-author of nine books, four edited books, 218 international journal papers and 330 refereed international conference papers. He has successfully supervised 38 Ph.D. students. These hold senior positions in major international universities and industry. He has presented 60 Keynote Addresses at major international conferences. Graham is a Distinguished Professor at Harbin Institute of Technology (China), Northwestern University (China), Zhengzhou University (China) and Universidad Técnica Federico Santa María (Chile). He holds several research grants covering diverse areas including Power Electronics, 3G and 4G Mobile Communications, Ambulance Scheduling, and Artificial Pancreas development. He holds 16 International Patents covering rolling mill technology, telecommunications, mine planning and mineral exploration.
This seminar is supported with funds from the Korhammer Lecture Series